Detoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents.

@article{Shibutani2010DetoxificationOA,
  title={Detoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents.},
  author={Shinya Shibutani and Radha Rani Bonala and Thomas A. Rosenquist and Robert Rieger and Naomi Suzuki and Francis Johnson and Frederick Miller and Arthur P. Grollman},
  journal={International journal of cancer},
  year={2010},
  volume={127 5},
  pages={1021-7}
}
Ingestion of aristolochic acids (AA) contained in herbal remedies results in aristolochic acid nephropathy (AAN), which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA I and AA II, primary components in AA, have similar genotoxic potential, whereas only AA I shows severe renal toxicity in rodents. AA I is demethylated to form 8-hydroxy-aristolochic acid I (AA Ia) as a major metabolite. However, the nephrotoxicity and genotoxicity of AA Ia has not… CONTINUE READING

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