Deterministic microfluidic ratchet based on the deformation of individual cells.

@article{Guo2011DeterministicMR,
  title={Deterministic microfluidic ratchet based on the deformation of individual cells.},
  author={Quan Wen Guo and Sarah Marie McFaul and Hongshen Ma},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  year={2011},
  volume={83 5 Pt 1},
  pages={
          051910
        }
}
We present a microfluidic ratchet that exploits the deformation of individual cells through microscale funnel constrictions. The threshold pressure required to transport single cells through such constrictions is greater against the direction of taper than along the direction of taper. This physical asymmetry combined with an oscillatory excitation can enable selective and irreversible transport of individual cells in low Reynolds number flow. We devised a microfluidic device to measure the… CONTINUE READING

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