Deterministic direct reprogramming of somatic cells to pluripotency

@article{Rais2013DeterministicDR,
  title={Deterministic direct reprogramming of somatic cells to pluripotency},
  author={Y. Rais and Asaf Zviran and Shay Geula and O. Gafni and Elad Chomsky and Sergey Viukov and A. Mansour and I. Caspi and V. Krupalnik and Mirie Zerbib and I. Maza and Nofar Mor and Dror Baran and L. Weinberger and Diego Jaitin and D. Lara-Astiaso and Ronnie Blecher-Gonen and Zohar Shipony and Zohar Mukamel and Tzachi Hagai and S. Gilad and D. Amann-Zalcenstein and A. Tanay and I. Amit and Noa Novershtern and J. Hanna},
  journal={Nature},
  year={2013},
  volume={502},
  pages={65-70}
}
Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (hereafter referred to as OSKM). The nature of the predominant rate-limiting barrier(s) preventing the majority of cells to successfully and synchronously reprogram remains to be defined. Here we show that depleting Mbd3, a core member of the Mbd3/NuRD (nucleosome remodelling and deacetylation) repressor complex… Expand
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