Determining thermodynamic parameters from isothermal calorimetric isotherms of the binding of macromolecules to metal cations originally chelated by a weak ligand.

@article{Hong2008DeterminingTP,
  title={Determining thermodynamic parameters from isothermal calorimetric isotherms of the binding of macromolecules to metal cations originally chelated by a weak ligand.},
  author={Lian Hong and William Derek Bush and Lanying Q. Hatcher and J. D. Simon},
  journal={The journal of physical chemistry. B},
  year={2008},
  volume={112 2},
  pages={
          604-11
        }
}
An accurate data analysis method for determining stoichiometry and thermodynamic parameters from isothermal titration calorimetry data for the binding of macromolecules to metal cations that are solubilized through an association with a weak ligand is presented. This approach is applied to determine the binding constant for the association of Cu(II) to the first 16 residues of the Alzheimer's amyloid beta peptide, Abeta(1-16) under conditions where Cu(II) is rendered soluble through weak… CONTINUE READING
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