Determining the relationship between "microvessel density" and different grades of astrocytoma based on immunohistochemistry for "factor VIII-related antigen" (von Willebrand factor) expression in tumor microvessels.

@article{Mahzouni2010DeterminingTR,
  title={Determining the relationship between "microvessel density" and different grades of astrocytoma based on immunohistochemistry for "factor VIII-related antigen" (von Willebrand factor) expression in tumor microvessels.},
  author={Parvin Mahzouni and Fereshteh Mohammadizadeh and Kourosh Mougouei and Noushin A. Moghaddam and Ali Chehrei and Alireza Mesbah},
  journal={Indian journal of pathology & microbiology},
  year={2010},
  volume={53 4},
  pages={605-10}
}
BACKGROUND Astrocytic brain tumors are the most common primary central nervous system tumors, which are classified into four grades. One of the most important pathologic criteria for the diagnosis of higher-grade astrocytomas (especially glioblastoma multiforme) is microvessel proliferation, particularly in the form of glomeruloid complex. Because tumor angiogenesis is a necessary factor for growth and invasiveness of malignancies, microvessel density (MVD) and intensity of angiogenesis may be… CONTINUE READING

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