Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT.

@article{Jin2005DeterminingTM,
  title={Determining the minimum number of detectable cardiac-transplanted 111In-tropolone-labelled bone-marrow-derived mesenchymal stem cells by SPECT.},
  author={Yuan Xiang Jin and Huafu Kong and Rob Z Stodilka and R. Glenn Wells and Pamela Zabel and Peter A Merrifield and Jane Sykes and Frank S. Prato},
  journal={Physics in medicine and biology},
  year={2005},
  volume={50 19},
  pages={4445-55}
}
In this work, we determined the minimum number of detectable 111In-tropolone-labelled bone-marrow-derived stem cells from the maximum activity per cell which did not affect viability, proliferation and differentiation, and the minimum detectable activity (MDA) of 111In by SPECT. Canine bone marrow mesenchymal cells were isolated, cultured and expanded. A number of samples, each containing 5x10(6) cells, were labelled with 111In-tropolone from 0.1 to 18 MBq, and cell viability was measured… CONTINUE READING