Determining the factors driving selective effects of new nonsynonymous mutations.

Abstract

The distribution of fitness effects (DFE) of new mutations plays a fundamental role in evolutionary genetics. However, the extent to which the DFE differs across species has yet to be systematically investigated. Furthermore, the biological mechanisms determining the DFE in natural populations remain unclear. Here, we show that theoretical models… (More)
DOI: 10.1073/pnas.1619508114

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