Determining the expected variability of immune responses using the cyton model.

@article{Subramanian2008DeterminingTE,
  title={Determining the expected variability of immune responses using the cyton model.},
  author={Vijay G. Subramanian and Ken R. Duffy and Marian L. Turner and Philip D. Hodgkin},
  journal={Journal of mathematical biology},
  year={2008},
  volume={56 6},
  pages={861-92}
}
During an adaptive immune response, lymphocytes proliferate for 5-20 cell divisions, then stop and die over a period of weeks. The cyton model for regulation of lymphocyte proliferation and survival was introduced by Hawkins et al. (Proc. Natl. Acad. Sci. USA 104, 5032-5037, 2007) to provide a framework for understanding this response and its regulation. The model assumes stochastic values for division and survival times for each cell in a responding population. Experimental evidence indicates… CONTINUE READING

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