Determining the effect of highly active antiretroviral therapy on changes in human immunodeficiency virus type 1 RNA viral load using a marginal structural left-censored mean model.

@article{Cole2007DeterminingTE,
  title={Determining the effect of highly active antiretroviral therapy on changes in human immunodeficiency virus type 1 RNA viral load using a marginal structural left-censored mean model.},
  author={Stephen R Cole and Miguel A. Hern{\'a}n and Kathryn M Anastos and Beth D. Jamieson and James M. Robins},
  journal={American journal of epidemiology},
  year={2007},
  volume={166 2},
  pages={219-27}
}
Highly active antiretroviral therapy (HAART) dramatically reduces the load of circulating human immunodeficiency virus type 1 (HIV-1) by blocking replication at multiple points in the viral life cycle, but the long-term effect of HAART on viral load remains unclear. In the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study, 918 HIV-1-infected men and women who were not using antiretroviral therapy were followed for a median of 5.8 years between 1996 and 2005. Follow-up yielded… CONTINUE READING
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