Determining the Optimal Timing for Initiation of Adjuvant Chemotherapy After Resection for Stage II and III Colon Cancer.

@article{Sun2016DeterminingTO,
  title={Determining the Optimal Timing for Initiation of Adjuvant Chemotherapy After Resection for Stage II and III Colon Cancer.},
  author={Zhifei Sun and Mohamed Abdelgadir Adam and Jina Kim and Daniel P. Nussbaum and Ehsan Benrashid and Christopher R. Mantyh and John Migaly},
  journal={Diseases of the colon and rectum},
  year={2016},
  volume={59 2},
  pages={
          87-93
        }
}
BACKGROUND Several reports suggest that the efficacy of adjuvant chemotherapy on survival diminishes over time for colon cancer; however, precise timing of its loss of benefit has not been established. OBJECTIVE This study aimed to determine the relationship between time to adjuvant chemotherapy and survival and to identify a threshold for increased risk of mortality. DESIGN This was a retrospective study. Multivariable Cox proportional hazard modeling with restricted cubic splines was used… CONTINUE READING
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Delay in Adjuvant Chemotherapy and Survival Advantage in Stage III Colon Cancer.

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