Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.

@article{Jakubowski2004DeterminingSA,
  title={Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.},
  author={Jennifer A Jakubowski and David A Keays and Wayne P Kelley and David W Sandall and J Bingham and Bruce G. Livett and Ken R Gayler and Jonathan V. Sweedler},
  journal={Journal of mass spectrometry : JMS},
  year={2004},
  volume={39 5},
  pages={548-57}
}
A combination of cDNA cloning and detailed mass spectrometric analyses was employed to identify novel conotoxins from Conus victoriae. Eleven conotoxin sequences were determined using molecular methods: one belonging to the A superfamily (Vc1.1), six belonging to the O superfamily (Vc6.1-Vc6.6) and four members of the T superfamily (Vc5.1-Vc5.4). In order to verify the sequences and identify the post-translational modifications (excluding the disulfide connectivity) of three Conus victoriae… CONTINUE READING

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