Determining K+ Channel Activation Curves from K+ Channel Currents Often Requires the Goldman–Hodgkin–Katz Equation

@inproceedings{Clay2009DeterminingKC,
  title={Determining K+ Channel Activation Curves from K+ Channel Currents Often Requires the Goldman–Hodgkin–Katz Equation},
  author={John R. Clay},
  booktitle={Front. Cell. Neurosci.},
  year={2009}
}
Potassium ion current in nerve membrane, I(K), has traditionally been described by I(K) = g(K)(V - E(K)), where g(K) is the K ion conductance, V is membrane potential and E(K) is the K(+) Nernst potential. This description has been unchallenged by most investigators in neuroscience since its introduction almost 60 years ago. The problem with the I(K) approximately (V - E(K)) proportionality is that it is inconsistent with the unequal distribution of K ions in the intra- and extracellular… CONTINUE READING
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