Determining DNA methylation profiles using sequencing.

@article{Feng2011DeterminingDM,
  title={Determining DNA methylation profiles using sequencing.},
  author={Suhua Feng and Liudmilla Rubbi and Steven E. Jacobsen and Matteo Pellegrini},
  journal={Methods in molecular biology},
  year={2011},
  volume={733},
  pages={
          223-38
        }
}
Cytosine methylation is an epigenetic mark that has a significant impact on the regulation of transcription and replication of DNA. DNA methylation patterns are highly conserved across cell divisions and are therefore highly heritable. Furthermore, in multicellular organisms, DNA methylation patterning is a key determinant of cellular differentiation and tissue-specific expression patterns. Lastly, DNA demethylases can affect global levels of DNA methylation during specific stages of… 
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