Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans.

@article{Hariprasad2004DeterminationOV,
  title={Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans.},
  author={Seenu M. Hariprasad and William Francis Mieler and Eric R. Holz and Hua Gao and J. E. Kim and Jingduan Chi and Randall A Prince},
  journal={Archives of ophthalmology},
  year={2004},
  volume={122 1},
  pages={42-7}
}
OBJECTIVE To investigate the penetration of voriconazole, a new-generation triazole antifungal agent, into the vitreous and aqueous humor after oral administration. METHODS A prospective, nonrandomized clinical study included 14 patients scheduled for elective pars plana vitrectomy surgery between December 1, 2002, and February 28, 2003, at the Cullen Eye Institute, Houston, Tex. Aqueous, vitreous, and plasma samples were obtained and analyzed from 14 patients after oral administration of two… CONTINUE READING
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