Determination of vhl gene mutations in sporadic renal cell carcinoma.

  title={Determination of vhl gene mutations in sporadic renal cell carcinoma.},
  author={Jos{\'e} M Gim{\'e}nez-Bachs and Antonio S Salinas and F. S{\'a}nchez-S{\'a}nchez and Juan G Lorenzo-Romero and Mar{\'i}a Jos{\'e} Donate-Moreno and H{\'e}ctor Pastor-Navarro and Dami{\'a}n Garc{\'i}a-Olmo and Julio Escribano-Mart{\'i}nez and Julio A Virseda-Rodr{\'i}guez},
  journal={European urology},
  volume={49 6},
OBJECTIVE Characterization of the molecular status of the vhl gene and its relationship to the usual prognostic factors could help establish new diagnostic and therapeutic strategies. This study determines the presence of vhl gene mutations in tumor tissue from patients with sporadic renal cell carcinoma, the relationship between the mutations and classic prognostic factors, and the possible impact on protein function. MATERIALS AND METHOD Cross-sectional analytical study investigating vhl… CONTINUE READING
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