Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography-mass spectrometry.

@article{Stephanson2005DeterminationOU,
  title={Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography-mass spectrometry.},
  author={Nikolai Stephanson and Helen Dahl and Anders Helander and Olof Beck},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2005},
  volume={816 1-2},
  pages={
          107-12
        }
}
5-Hydroxytryptophol glucuronide (GTOL) is the major excretion form of 5-hydroxytryptophol (5-HTOL), a minor serotonin metabolite under normal conditions. Because the concentration of 5-HTOL is markedly increased following consumption of alcohol, measurement of 5-HTOL is used as a sensitive biomarker for detection of recent alcohol intake. This study describes the development and evaluation of a liquid chromatography-electrospray ionization mass spectrometry (LC-MS) procedure for direct… CONTINUE READING
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