Determination of time to onset and rate of action of insulin products: importance and new approaches.

@article{Jain2013DeterminationOT,
  title={Determination of time to onset and rate of action of insulin products: importance and new approaches.},
  author={Lokesh Jain and M. H. Parks and Chandrahas G. Sahajwalla},
  journal={Journal of pharmaceutical sciences},
  year={2013},
  volume={102 1},
  pages={271-9}
}
One important aspect of insulin drug development is to ascertain that short-acting insulins mimic the normal mealtime insulin release in healthy subjects. Therefore, it is important to identify metrics that allow identification of unique characteristics of insulin products based on pharmacokinetic (PK) (time-concentration) or glucodynamic (time course of action) profiles. Current development programs use metrics such as "onset of action" to characterize insulin products, in addition to peak and… CONTINUE READING