Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus.

@article{Ikeda2001DeterminationOT,
  title={Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus.},
  author={Tohru Ikeda and Michiyuki Kasai and Masanori Utsuyama and Katsuiku Hirokawa},
  journal={Endocrinology},
  year={2001},
  volume={142 4},
  pages={1419-26}
}
The receptor activator of nuclear factor (NF)-kappaB ligand [RANKL; also known as tumor necrosis factor-related activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor] is known to bind with the receptor activator of NF-kappaB (RANK) and act not only as a key factor for osteoclastogenesis but also as a regulator of lymphocyte development. In this study, we found two additional isoforms of RANKL. RANKL 2 has a shorter intracellular domain than the original… CONTINUE READING