Determination of the underivatized antineoplastic drugs cyclophosphamide and 5-fluorouracil and some of their metabolites by capillary gas chromatography combined with electron-capture and nitrogen-phosphorus selective detection.

@article{Bruin1983DeterminationOT,
  title={Determination of the underivatized antineoplastic drugs cyclophosphamide and 5-fluorouracil and some of their metabolites by capillary gas chromatography combined with electron-capture and nitrogen-phosphorus selective detection.},
  author={E A de Bruin and Ubbo R. Tjaden and Allan T. van Oosterom and Peter Leeflang and Piet A. Leclercq},
  journal={Journal of chromatography},
  year={1983},
  volume={279},
  pages={
          603-8
        }
}
A rapid and sensitive method for the determination of cyclophosphamide (CP) and 5-fluorouracil (5-FU) and some of their metabolites in one analysis has been developed. Surface-coated open-tubular OV-275 columns were combined with electron-capture detection and nitrogen-phosphorus selective detection. The influence of the column diameter on the separation is shown. Extraction with 2-propanol-diethyl ether (22:77) allows the isolation of CP, 5-FU and their analogues in one extraction step. The… CONTINUE READING
BETA

Similar Papers

Loading similar papers…