Determination of the systematic and random measurement error in an LC-FTICR mass spectrometry analysis of a partially characterized complex peptide mixture

Abstract

In high-throughput proteomics, a promising approach presently being explored is the use of liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR-MS) to provide measurements of the masses of tryptic peptides in complex mixtures, which can then be used to identify the proteins which gave rise to those peptides… (More)

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