Determination of the sub-lethal nephrotoxic dose of Russell's viper (Daboia russelii) venom in Wistar rats.

@article{Wijewickrama2018DeterminationOT,
  title={Determination of the sub-lethal nephrotoxic dose of Russell's viper (Daboia russelii) venom in Wistar rats.},
  author={Eranga Sanjeewa Wijewickrama and Ishani Kurukulasooriya and Mangala Gunatilake and Amarathunga A H Priyani and Ariaranee Gnanathasan and Indika Bandara Gawarammana and Geoffrey K Isbister},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2018},
  volume={152},
  pages={
          43-45
        }
}
Wistar rats were administered increasing doses of Russell's viper venom (RVV; 0.025-0.4 mg/kg) intraperitoneally to investigate acute kidney injury (AKI) by measuring creatinine (1.5-fold increase in serum creatinine above baseline) and examining kidney histology. Approximately 50% of rats receiving 0.25-0.4 mg/kg venom died within 72 h. An increase in serum creatinine only occurred at a venom dose of 0.4 mg/kg, except in two rats. Acute tubular necrosis, glomerular necrosis, cortical necrosis… CONTINUE READING
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