Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions.

@article{Asano2017DeterminationOT,
  title={Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions.},
  author={Marie Asano and Hideo Iwahashi},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={127},
  pages={740-747}
}
While artemisinin 1 has been widely used to treat malaria in traditional Chinese medicine, its exact antimalarial mechanism remains unclear. To elucidate the mechanisms of the antimalarial action by artemisinin, the reactions of artemisinin, artemether 2 and artesunate 3 with Fe2+ were analyzed using an electron spin resonance (ESR), high performance liquid… CONTINUE READING