Determination of the sequences of protein-derived peptides and peptide mixtures by mass spectrometry.

@article{Morris1971DeterminationOT,
  title={Determination of the sequences of protein-derived peptides and peptide mixtures by mass spectrometry.},
  author={Howard R. Morris and D. H. Williams and Richard P Ambler},
  journal={The Biochemical journal},
  year={1971},
  volume={125 1},
  pages={189-201}
}
Micro-quantities of protein-derived peptides have been converted into N-acetylated permethyl derivatives, and their sequences determined by low-resolution mass spectrometry without prior knowledge of their amino acid compositions or lengths. A new strategy is suggested for the mass spectrometric sequencing of oligopeptides or proteins, involving gel… CONTINUE READING