Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.

@article{Ito1997DeterminationOT,
  title={Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.},
  author={Toshihiro Ito and Michael M C Lai},
  journal={Journal of virology},
  year={1997},
  volume={71 11},
  pages={8698-706}
}
Hepatitis C virus (HCV) contains a positive-stranded RNA genome of approximately 9.5 kb. Despite the overall sequence diversity among individual HCV isolates, the 3'-end 98 nucleotides (nt) of the HCV RNA, which constitute part of the 3'-untranslated region (3'-UTR), are highly conserved. This conserved region may contain the cis-acting signals for RNA replication involving possibly both viral and cellular proteins. We carried out RNase digestion studies, which revealed that this 98-nt region… CONTINUE READING

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NucleotidesNo subtypeRNA
Despite the overall sequence diversity among individual HCV isolates , the 3'-end 98 nucleotides ( nt ) of the HCV RNA , which constitute part of the 3'-untranslated region ( 3'-UTR ) , are highly conserved .
RNANo subtypeNucleotides
Despite the overall sequence diversity among individual HCV isolates , the 3'-end 98 nucleotides ( nt ) of the HCV RNA , which constitute part of the 3'-untranslated region ( 3'-UTR ) , are highly conserved .
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