Determination of the safety of leucine supplementation in healthy elderly men

@article{Rasmussen2016DeterminationOT,
  title={Determination of the safety of leucine supplementation in healthy elderly men},
  author={Betina F Rasmussen and Erin Gilbert and Abrar Turki and Kenneth Michael Madden and Rajavel Elango},
  journal={Amino Acids},
  year={2016},
  volume={48},
  pages={1707-1716}
}
Leucine, a branched-chain amino acid (BCAA), has been shown to stimulate muscle protein synthesis, and thus has been proposed to prevent age-related muscle atrophy (sarcopenia). Therefore, leucine supplementation may have potential benefits in elderly populations to preserve muscle mass. The tolerable upper intake level (UL) for leucine intake in young men has recently been determined to be 500 mg kg−1 day−1, and increases in blood ammonia concentrations were seen at intake levels above 500 mg… 
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