Determination of the retinobenzoic acid derivative Am580 in rat plasma by high-performance liquid chromatography.


A specific liquid chromatographic method for the determination of 4-[[(5,6,7,8,8-tetrahydro-5,5,8,8-tetramethyl-2- naphthalenyl)carbonyl]amino]benzoic acid (Am580) in rat plasma is described. The procedure includes one-step isolation of the compound and the internal standard (naphthol AS) from protein precipitated with acetonitrile, resolution on a reversed… (More)


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