Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.

@article{Shen1999DeterminationOT,
  title={Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.},
  author={Jie Shen and Kitt Falk Petersen and Kevin L. Behar and Paul Brown and T W Nixon and Graeme F. Mason and Ognen A. C. Petroff and Gerald I Shulman and Robert G. Shulman and Douglas L. Rothman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 14},
  pages={8235-40}
}
Recent 13C NMR studies in rat models have shown that the glutamate/glutamine cycle is highly active in the cerebral cortex and is coupled to incremental glucose oxidation in an approximately 1:1 stoichiometry. To determine whether a high level of glutamatergic activity is present in human cortex, the rates of the tricarboxylic acid cycle, glutamine synthesis, and the glutamate/glutamine cycle were determined in the human occipital/parietal lobe at rest. During an infusion of [1-13C]-glucose, in… CONTINUE READING
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