Corpus ID: 1090969

Determination of the putative binding site for fibronectin on platelet glycoprotein IIb-IIIa complex through a hydropathic complementarity approach.

@article{Pasqualini1989DeterminationOT,
  title={Determination of the putative binding site for fibronectin on platelet glycoprotein IIb-IIIa complex through a hydropathic complementarity approach.},
  author={R. Pasqualini and D. F. Chamone and R. Brentani},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 24},
  pages={
          14566-70
        }
}
  • R. Pasqualini, D. F. Chamone, R. Brentani
  • Published 1989
  • Biology, Medicine
  • The Journal of biological chemistry
  • We have applied the principle of complementary hydropathy to the prediction of the binding site for fibronectin (FN) and for the alpha-chain of fibrinogen in the platelet receptor complex glycoprotein (GP) IIb-IIIa. Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins. The deduced peptides were very… CONTINUE READING
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