Determination of the preferred conditions for the isolated perfusion of porcine kidneys.

@article{Mancina2015DeterminationOT,
  title={Determination of the preferred conditions for the isolated perfusion of porcine kidneys.},
  author={Elina Mancina and Julia Kalenski and Pascal Paschenda and Christian Beckers and Christian Bleilevens and Peter Boor and Benedict Maria Doorschodt and Ren{\'e} Hany Tolba},
  journal={European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes},
  year={2015},
  volume={54 1-2},
  pages={44-54}
}
BACKGROUND The isolated perfused porcine kidney (IPPK) model has been the method of choice for the early preclinical evaluation of kidney graft preservation techniques. The preferred reperfusion conditions have not yet been determined. Here, we examined the effects of pressure- or flow-controlled perfusion and oxygenation by pure oxygen or carbogen (95% O2/5% CO2) on normothermic reperfusion in the IPPK model. METHODS Porcine kidneys were cold-stored for 24 h in histidine-tryptophan… CONTINUE READING
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