Determination of the precursor frequency and the reaction intensity of xenoreactive human T lymphocytes.

@article{Tahara2010DeterminationOT,
  title={Determination of the precursor frequency and the reaction intensity of xenoreactive human T lymphocytes.},
  author={Hiroyuki Tahara and Kentaro Ide and Nabin Bahadur Basnet and Yuka Tanaka and Hideki Ohdan},
  journal={Xenotransplantation},
  year={2010},
  volume={17 3},
  pages={188-96}
}
BACKGROUND It is acknowledged that the response of human T cells to xenogeneic targets is more potent than that to allogeneic targets. However, it is not clear whether the more vigorous T cell response to xenoantigens than to alloantigens is attributable to a higher frequency or stronger reaction of xenoreactive T cells. METHODS We determined the precursor frequencies (PFs) and stimulation indexes (SIs) of xenoreactive human T cells by performing a mixed lymphocyte reaction (MLR) assay using… CONTINUE READING