Determination of the optimal dosage regimen of captopril + hydrochlorothiazide in the treatment of moderate arterial hypertension.

@article{Stru1987DeterminationOT,
  title={Determination of the optimal dosage regimen of captopril + hydrochlorothiazide in the treatment of moderate arterial hypertension.},
  author={Dominique St{\'e}ru and M E Childs and Sylvie Lancrenon and J M Languillat and A Mattei and Bernard Millet and A Schwebig and Antoine G Stephan},
  journal={British journal of clinical pharmacology},
  year={1987},
  volume={23 Suppl 1},
  pages={65S-69S}
}
A multicentre controlled trial was carried out to determine the optimal dosage of a 2/1 combination of captopril plus hydrochlorothiazide (HCTZ) in mild hypertension at three doses against placebo in a 6 week double-blind trial. The number of patients was 111:27 received placebo; 26 were treated with captopril 25 mg plus HCTZ 12.5 mg (25/12.5); 25 with… CONTINUE READING