Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat

Although the murine retrovirus SL3-3 is highly leukaemo-genic1,2, in both the structure of its genome and in its properties of replication in tissue culture it closely resembles the non-leukaemogenic retrovirus Akv (refs 3, 4). An.earlier investigation of the properties of recombinant SL3-3-Akv viruses localized the major determinant of leukaemogenicity… CONTINUE READING