Determination of the free and total concentrations of vancomycin by two-dimensional liquid chromatography and its application in elderly patients.


A robust two-dimensional liquid chromatography (2D-LC) method for determining the free and total concentrations of vancomycin in plasma was developed and validated. The 2D-LC system, which exhibited a strong capacity for inhibiting interference, comprised a unique RP1-IEX-RP2 column system and an "Assistant Flow" configuration. Ultrafiltration technology… (More)
DOI: 10.1016/j.jchromb.2014.08.002


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