Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC.

Abstract

A stereoselective HPLC assay has been developed to analyze the enantiomers of citalopram and of its three main metabolites in plasma after their separation on a Chiracel OD column. Using a fluorescence detector, the limit of quantification in plasma samples was 15, 4, 5 and 2 ng/ml for the enantiomers of citalopram (CIT), desmethylcitalopram (DCIT… (More)

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@article{Rochat1995DeterminationOT, title={Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC.}, author={Bertrand Rochat and Mark Amey and H H van Gelderen and Bernard Testa and Pierre Baumann}, journal={Chirality}, year={1995}, volume={7 6}, pages={389-95} }