Determination of the effect of lipophilicity on the in vitro permeability and tissue reservoir characteristics of topically applied solutes in human skin layers.

@article{Cross2003DeterminationOT,
  title={Determination of the effect of lipophilicity on the in vitro permeability and tissue reservoir characteristics of topically applied solutes in human skin layers.},
  author={Sheree E. Cross and Beatrice M. Magnusson and Gareth Winckle and Yuri G. Anissimov and Michael S. Roberts},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={120 5},
  pages={759-64}
}
In order to establish the relationship between solute lipophilicity and skin penetration (including flux and concentration behavior), we examined the in vitro penetration and membrane concentration of a series of homologous alcohols (C2-C10) applied topically in aqueous solutions to human epidermal, full-thickness, and dermal membranes. The partitioning/distribution of each alcohol between the donor solution, stratum corneum, viable epidermis, dermis, and receptor phase compartments was… CONTINUE READING

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