Determination of the dose proportionality of single intravenous doses (5, 10, and 15 mg) of lubeluzole in healthy volunteers.

@article{Herron1998DeterminationOT,
  title={Determination of the dose proportionality of single intravenous doses (5, 10, and 15 mg) of lubeluzole in healthy volunteers.},
  author={Jerry Herron and Peter Nan-shong Lee and Luana Pesco-Koplowitz and D Gajjar and Yuhwen Soo and R J Woestenborghs},
  journal={Clinical therapeutics},
  year={1998},
  volume={20 4},
  pages={
          682-90
        }
}
The dose proportionality of lubeluzole, a drug in clinical development for the treatment of acute ischemic stroke, was evaluated in a Phase I, single-center, open-label, randomized-dosing-sequence, three-way crossover clinical trial in 12 healthy adults. An equal number of male and female volunteers were enrolled in the trial, with a mean weight (+/- SD) of 73.2 +/- 11.9 kg, mean height (+/- SD) of 66.8 +/- 4.6 inches, and a mean age of 36.1 +/- 5.2 years. Subjects received intravenous… CONTINUE READING