Determination of the dissociation constant of a weak acid using a dissolution rate method.

Abstract

Based on theories of diffusion-controlled mass transport for dissolution processes of weak acids in aqueous alkaline media, a method for the determination of the dissociation constant of a weak monoprotic acid is described. The method includes measurements of the initial dissolution rate as a function of pH, using the rotating-disk technique, and… (More)

Cite this paper

@article{Hansen1983DeterminationOT, title={Determination of the dissociation constant of a weak acid using a dissolution rate method.}, author={J. Bo Hansen and O Hafliger}, journal={Journal of pharmaceutical sciences}, year={1983}, volume={72 4}, pages={429-31} }