Determination of the depth of bromine atoms in bilayers formed from bromolipid probes.

@article{McIntosh1987DeterminationOT,
  title={Determination of the depth of bromine atoms in bilayers formed from bromolipid probes.},
  author={Thomas J. McIntosh and Peter Holloway},
  journal={Biochemistry},
  year={1987},
  volume={26 6},
  pages={1783-8}
}
X-ray diffraction analysis has been performed on a series of 1-palmitoyl-2-dibromostearoyl-phosphatidylcholines (BRPCs) with bromine atoms at the 6, 7-, the 11, 12-, or the 15, 16-positions on the sn-2 acyl chains. The diffraction patterns indicate that, when hydrated, each of these lipids forms liquid-crystalline bilayers at 20 degrees C. For each lipid, electron density profiles and continuous Fourier transforms were calculated by the use of swelling experiments. In the electron profiles… CONTINUE READING

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