Determination of the Viscosity of an Amorphous Drug Using Thermomechanical Analysis (TMA)

@article{Hancock1999DeterminationOT,
  title={Determination of the Viscosity of an Amorphous Drug Using Thermomechanical Analysis (TMA)},
  author={Bruno C. Hancock and Yves Dupuis and Roch Thibert},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={672-675}
}
Purpose. To evaluate thermomechanical analysis (TMA) as a technique for determining the viscosity of amorphous pharmaceutical materials. This property of amorphous drugs and excipients is related to their average rate of molecular mobility and thus to their physical and chemical stability. Methods. Indomethacin was selected as a model amorphous drug whose viscosity has previously been reported in the literature. A Seiko TMA 120C thermomechanical analyzer was utilized in isothermal penetration… CONTINUE READING