Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo *

@article{Rensen2001DeterminationOT,
  title={Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo *},
  author={P. Rensen and L. Sliedregt and M. Ferns and E. Kieviet and S. M. V. van Rossenberg and S. H. van Leeuwen and T. V. van Berkel and E. Biessen},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={37577 - 37584}
}
The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine (GalNAc) ≫ galactose) and the effects of ligand valency (tetraantennary > triantennary ≫ diantennary ≫ monoantennary) and sugar spacing (20 Å ≫ 10 Å ≫ 4 Å) are well documented, the effect of particle size on recognition and uptake of ligands by the receptor is poorly defined. In the present study, we assessed the… Expand
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