Determination of the Stability Constants for Inclusion Complexes of Cyclodextrins with Various Drug Molecules by High Performance Liquid Chromatography

  title={Determination of the Stability Constants for Inclusion Complexes of Cyclodextrins with Various Drug Molecules by High Performance Liquid Chromatography},
  author={K. Uekama and F. Hirayama and S. Nasu and N. Matsuo and T. Irie},
  journal={Chemical \& Pharmaceutical Bulletin},
Stability constant (Ke) for 1 : 1 inclusion complexes of α-and β-cyclodextrins with barbiturates, phenothiazines, sulfonylamides, and sulfonylureas were determined by high performance liquid chromatography (HPLC). The retention times of the drugs following the binding to cyclodextrins in aqueous mobile phase on ion exchange support were quantitatively treated to obtain the Ke values. The Ke values obtained by HPLC method were in fair agreement with those obtained by other methods such as… Expand
Simple Prediction of Stability Constants for Inclusion Complexes of β-Cyclodextrin with various Drug Molecules Using β-Cyclodextrin Bonded Phases(Cyclobond I Column)
AbstractThe stability constants(Kc) for inclusion complexes of cyclodextrin with sulfonamides, sulfonylureas and p-aminobenzoic acid esters were investigated by high performance liquid chromatographyExpand
Account of Analytical Techniques Employed for the Determination of Thermodynamics of Inclusion Complexation of Drugs with Cyclodextrins
Inclusion complexation of drugs with cyclodextrins is evolved in the recent past as an important phenomenon to increase the solubility, stability, and bioavailability of drugs along with masking ofExpand
Application of gel chromatography to determining formation constants of inclusion compounds of cyclodextrins
The gel filtration technique (Hummel and Dreyer method) was applied to determining formation constants of inclusion complexes of α- and β-cyclodextrins. As guest substances, p-nitrophenolate,Expand
Determination of association constants of β-cyclodextrin and β-cyclodextrin-bearing polymers with drugs by high-performance liquid chromatography
Abstract A high-performance liquid chromatographic (HPLC) support was prepared, based on silica beads coated with a β-cyclodextrin-containing polymer, which allows the elution of solutes in order ofExpand
Charge-transfer chromatographic study on the inclusion complex formation of some barbituric acid derivatives with varrious cyclodextrins
SummaryThe inclusion complexing capacity of 21 barbituric acid derivatives with α-, β- and γ-cyclodextrins, with a water soluble β-cyclodextrin polymer and with 2,6-di-O-methyl-β-cyclodextrin wasExpand
The interaction of γ-cyclodextrin with a series of six polycyclic aromatic hydrocarbons (PAHs) (naphthalene, fluorene, anthracene, phenanthrene, fluoranthene, and pyrene) was studied by highExpand
Characterization of inclusion complexes of betamethasone-related steroids with cyclodextrins using high-performance liquid chromatography.
The usefulness of cyclodextrins to achieve the separation of steroids in HPLC is discussed and a practical application for the analysis of a steroid and three potential impurities is described. Expand
Quantitative structure-stability relationships among inclusion complexes of cyclodextrins. I: Barbituric acid derivatives.
Quantitative structure-stability relationships are formulated for the inclusion complexation of 17 barbituric acid derivatives with alpha- and beta-cyclodextrin and the results suggest that in alpha-cyclodesxtrin-barbiturate complexes the cyclODExtrin cavity includes only R1, while in beta- cyclodextrine complexes both R1 and (part of) the barbiturate ring are included. Expand
Retention characteristics of several compound classes in reversed-phase liquid chromatography with β-cyclodextrin as a mobile phase modifier
Abstract β-Cyclodextrin was investigated as a mobile phase modifier in the reversed-phase liquid chromatography of polycyclic aromatic hydrocarbons, nitrogen hetero-cycles and hydroxyl aromatics. AExpand
A Note on Complexation of Dansyl Amino Acid Enantiomers by β-Cyclodextrin Studied by High Performance Liquid Chromatography and Fluorescence Measurements
It has been shown recently[1] that dansyl (1dimethylaminonaphthalene-5-sulphonyl) amino acids can be resolved on a reversed-phase HPLC column by incorporation of β-cyclodextrin into the mobile phase.Expand