Determination of the DNA content of human chromosomes by flow cytometry.

@article{Harris1986DeterminationOT,
  title={Determination of the DNA content of human chromosomes by flow cytometry.},
  author={Peter Harris and E. Boyd and Bryan D. Young and M. A. Ferguson-Smith},
  journal={Cytogenetics and cell genetics},
  year={1986},
  volume={41 1},
  pages={14-21}
}
The mean relative DNA content of each human chromosome was calculated from flow karyotypes of ethidium bromide-stained chromosomes obtained from healthy, normal individuals. These values were found to correlate closely with previously published data obtained by photometric scanning of stained, fixed chromosomes. Calculations of the normal variation in DNA content of each human chromosome indicated that chromosomes 1, 9, 16, and Y (chromosomes with large centric heterochromatic regions) were the… CONTINUE READING

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