[Determination of tetracyclines by flow injection analysis].


An accurate, convenient and fast method was proposed for the determination of tetracyclines (tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline) and their preparations by flow injection detector based on tetracycline flow-through sensor. The parameters affecting the measurement were discussed. The detector can respond to tetracycline, chlortetracycline, oxytetracycline, doxycycline and methacycline, at the same time. Their slopes are 51-55 mV/decade over the concentration range of 10(-2)-5 x 10(-5) mol/L at pH 1.5-3.5. The results obtained are in good agreement with those by biological assay (less than 3% deviation). One hundred samples can be determined in an hour.

Cite this paper

@article{Liu1991DeterminationOT, title={[Determination of tetracyclines by flow injection analysis].}, author={W Z Liu and Hua Jiang and Aiming Du}, journal={Yao xue xue bao = Acta pharmaceutica Sinica}, year={1991}, volume={26 5}, pages={391-4} }