Determination of starting materials, intermediates, and subsidiary colors in the color additive Food Red No. 106 (Sulforhodamine B) using high-performance liquid chromatography.

@article{Tatebe2017DeterminationOS,
  title={Determination of starting materials, intermediates, and subsidiary colors in the color additive Food Red No. 106 (Sulforhodamine B) using high-performance liquid chromatography.},
  author={Chiye Tatebe and Takashi Ohtsuki and Tsuyoshi Fujita and Koji Nishiyama and S Itoh and Naoki Sugimoto and Hiroki Kubota and Atsuko Tada and Kyoko Sato and Hiroshi Akiyama},
  journal={Food chemistry},
  year={2017},
  volume={237},
  pages={
          733-742
        }
}
The main subsidiary color of structure in Food Red No. 106 (R106) was identified to be a desethyl derivative (R106-SubA). High-performance liquid chromatography (HPLC) was performed for the quantitative determination of benzaldehyde-2,4-disulfonic acid, N,N-diethyl-m-aminophenol, leuco acid, pyrone acid, R106-SubA, etc. in R106. An ammonium acetate solution (20mM) and acetonitrile:water (7:3) were used to stabilize the retention time of the HPLC analytes. The linearity of the calibration curves… 
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