Determination of some histamine H1-receptor antagonists in dosage forms.

  title={Determination of some histamine H1-receptor antagonists in dosage forms.},
  author={Azza Abdel Kader Gazy and H. E. Mahgoub and Fawzi A El-Yazbi and Mahmoud A El-Sayed and Rasha M. Youssef},
  journal={Journal of pharmaceutical and biomedical analysis},
  volume={30 3},
Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured spectrophotometrically. Secondly, eosin gives with these drugs ion-pair complex, measurable directly without extraction both spectrophotometrically and… CONTINUE READING
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