Determination of sisomicin, netilmicin, astromicin and micronomicin in serum by high-performance liquid chromatography.


A high-performance liquid chromatographic method for monitoring serum levels of the aminoglycoside antibiotics sisomicin, netilmicin, astromicin, and micronomicin, using an amino acid analysis system is described. The procedure involves sample preparation with a CM-Sephadex column, and quantitation using internal standards chosen from each of the other… (More)


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