Determination of serum calcitonin by immunometric two-site assays in normal subjects and patients with medullary thyroid carcinoma.

@article{Zink1992DeterminationOS,
  title={Determination of serum calcitonin by immunometric two-site assays in normal subjects and patients with medullary thyroid carcinoma.},
  author={Anne Zink and Eberhard Blind and F Raue},
  journal={European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies},
  year={1992},
  volume={30 12},
  pages={831-5}
}
We evaluated the clinical usefulness of a commercial two-site immunoassay for calcitonin, which is based on two monoclonal antibodies against distinct epitopes of calcitonin. The potential lower detection limit of the assay was 2 ng/l. Inter-assay and intra-assay variation were both < 11%. No cross reaction with calcitonins from different species (salmon and eel calcitonin) was found. Of the various fragments of human calcitonin, only the 11-32 fragment could be detected. Basal calcitonin… CONTINUE READING
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