Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method.

@article{Nogueira2008DeterminationOR,
  title={Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method.},
  author={Daniele Rubert Nogueira and Maximiliano da Silva Sangoi and Luc{\'e}lia Magalh{\~a}es da Silva and V{\'i}tor Todeschini and S{\'e}rgio Luiz Dalmora},
  journal={Journal of separation science},
  year={2008},
  volume={31 16-17},
  pages={3098-105}
}
A stability-indicating MEKC was developed and validated for the analysis of rupatadine in tablet dosage forms, using nimesulide as internal standard. The MEKC method was performed on a fused-silica capillary (50 microm id; effective length, 40 cm). The BGE consisted of 15 mM borate buffer and 25 mM anionic detergent SDS solution at pH 10. The capillary temperature was maintained at 35 degrees C and the applied voltage was 25 kV. The injection was performed using the hydrodynamic mode at 50 mbar… CONTINUE READING