Determination of receptors that mediate opiate side effects in the mouse.

@article{Hayes1983DeterminationOR,
  title={Determination of receptors that mediate opiate side effects in the mouse.},
  author={Ann Hayes and Michael B. Tyers},
  journal={British journal of pharmacology},
  year={1983},
  volume={79 3},
  pages={731-6}
}
The effects of mu and kappa-opiate receptor agonists were studied in a variety of tests in the mouse designed to correspond to clinical side-effects in man. These included sedation, decrease in pupil diameter, Straub tail, decrease in body temperature, decrease in respiratory rate and inhibition of gut propulsion. The mu-receptor agonists tested produced opiate side-effects in the mouse at doses between 2.4 and 34 times higher than their antinociceptive doses in the abdominal constriction test… CONTINUE READING