Determination of rate order for degradation of drugs with nonisothermal stability experiment.

@article{Zhan1997DeterminationOR,
  title={Determination of rate order for degradation of drugs with nonisothermal stability experiment.},
  author={X C Zhan and G. Yin and B Ma},
  journal={Journal of pharmaceutical sciences},
  year={1997},
  volume={86 10},
  pages={1099-104}
}
The inability of ordinary nonisothermal experiments to determine the rate order (n) of drug degradation is discussed on the basis of a theoretical study of simulated nonisothermal data. In ordinary nonisothermal experiments, using either r or sigma(C[experiment] C[compute])2 as the measure of goodness of fit, the rate order cannot be assessed because the same set of c-t data can be well fitted by different combinations of estimates for n and the activation energy (E). Hence, a new nonisothermal… CONTINUE READING

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